Science
INTELLIGENCE CODE
With our immune system supplement, we harness our bodies’ natural intelligence—and let the power of the ingredients emerge.
INGREDIENTS
Each element is carefully chosen to work in concert. Fierce Immunity is
an unprecedented combination you won’t find anywhere else.
vitamin d
Vitamin D is obtained from sun exposure, foods, and supplements. These sources supply vitamin D in a biologically inactive form. When activating vitamin D, the liver and the kidney transform the inactive form into the physiologically active form, known as calcitriol.
Fierce Immunity is designed to help activate vitamin D and increase calcitriol production. And, unlike other vitamin D supplements, the addition of quercetin can help increase the bioavailability of vitamin D, and arginine can help increase its efficacy.
The correlation between a Th1/Th2 cytokines imbalance and vitamin D level in patients with early chronic obstructive pulmonary disease (COPD), based on screening results (link).
Vitamin D Regulation of Immune Function (link).
The influence of vitamin D on M1 and M2 macrophages in patients with Crohn's disease (link).
quercetin
Quercetin, a flavonol found in many fruits and vegetables, not only kills bacteria and viruses, but also supports the immune system by increasing the production of immune effector cells. Combined with hesperidin, quercetin can help protect memory functions and slow cognitive decline.
Since quercetin also can increase the oral bioavailability of vitamin D and support its activation, it can help increase the protective power of vitamin D. Additionally, quercetin can help regulate overproduction of nitric oxide from the I-arginine in Fierce Immunity.
Modulation of Th1/Th2 Cytokine Balance by Quercetin In Vitro (link).
Quercetin, Inflammation and Immunity (link).
Neuroprotective Potentials of Flavonoids: Experimental Studies and Mechanisms of Action (link).
Influence of the Neuroprotective Properties of Quercetin on Regeneration and Functional Recovery of the Nervous System (link).
Regulatory Effects of Quercetin on M1/M2 Macrophage Polarization and Oxidative/Antioxidative Balance (link).
hesperidin
Hesperidin, a flavanone contained in citrus fruits, is a time-honored herbal medicine that was first isolated in 1828. By reducing viral replication, it helps protect against influenza. Hesperidin can reduce inflammation, support the production of immune effector cells, and more.
The safety of hesperidin was confirmed by FASEB (Federation of American Societies of Experimental Biology) upon request of the FDA. Toxicity studies have confirmed the high safety profile of hesperidin after oral intake.
FDA GRAS notices for hesperidin (link).
ChEBI: Hesperidin (link).
Experimental immunology - Differential effect of hesperidin on Th1, Th2, Th17, and proinflammatory cytokines production from splenocyte of Schistosoma mansoni-infected mice (link).
Hesperidin as a Neuroprotective Agent: A Review of Animal and Clinical Evidence (link).
Hesperidin inhibits synovial cell inflammation and macrophage polarization through suppression of the PI3K/AKT pathway in complete Freund's adjuvant-induced arthritis in mice (link).
Orange juice and hesperidin promote differential innate immune response in macrophages ex vivo (link).
Zinc Ascorbate
Zinc ascorbate is the zinc salt of vitamin C. It has superoxide dismutase-like and antibacterial activity. The combination of zinc and vitamin C supports the innate immune system only when consumed in moderate amounts. Too much zinc weakens, rather than strengthens, the innate immune system.
This function can help increase the efficacy of quercetin and hesperidin, as well as the immune-supporting power of Fierce Immunity.
Clinical efficacy of zinc supplementation in improving antioxidant defense system: A comprehensive systematic review and time-response meta-analysis of controlled clinical trials (link).
Zinc supplementation reduces Candida infections in pediatric intensive care unit: a randomized placebo-controlled clinical trial (link).
Inflammatory response under zinc deficiency is exacerbated by dysfunction of the T helper type 2 lymphocyte-M2 macrophage pathway (link).
L-Arginine
L-arginine serves as a building block for proteins and plays an essential role in the immune and cardiovascular systems. This amino acid is essential to nitric oxide production in the body, which can improve blood flow and heart health.
L-arginine can increase the activation of vitamin D, which is designed to help increase the ability of Fierce Immunity to unlock the immune system’s full potential.
Intravenous arginine administration benefits CD4+ T-cell homeostasis and attenuates liver inflammation in mice with polymicrobial sepsis (link).
Arginine-dependent immune responses (link).
Effect of L-arginine on immune function: a meta-analysis (link).
Functional characterization of nutraceuticals using spectral clustering: Centrality of caveolae-mediated endocytosis for management of nitric oxide and vitamin D deficiencies and atherosclerosis (link).
OUR FORMULATORS
DR. ANTON FLIRI
Anton Fliri, Ph.D., J.D., is a distinguished professional with expertise in Organic Chemistry and Law. He is the President and Co-founder of SystaMedic Inc., the Founder and President of Emergent System Analytics LLC, and the Chief Technology Officer of Wellomics LLC. Additionally, he serves as a Scientific Advisor and Co-founder of Decript Inc. and is a member of the American and Swiss Chemical Societies.
Dr. Fliri obtained his Ph.D. in Organic Chemistry in 1979 from the Leopold Franzens University in Innsbruck, Austria. He conducted postdoctoral research at Harvard University with Nobel Laureate R. B. Woodward (1978–1980) and at ETH Zurich with Wolf Prize winner Albert Eschenmoser (1980–1982). With a focus on natural product research, Dr. Fliri joined Pfizer in 1982, where he conducted research in cancer and neuroscience. He founded Decript Inc. in collaboration with the French Patent Department in 2007, pioneering technology for evaluating the novelty of pharmaceutical inventions. For this groundbreaking work, Dr. Fliri received two Pfizer Central Research Achievement awards. His accomplishments in pharmaceutical research are evident through over 100 patents, publications, and speaking engagements.
In 2009, Dr. Fliri established SystaMedic Inc., a biotech company specializing in life science data analysis. Applying the technology developed by SystaMedic in the field of wellness and natural medicine, he joined the nutraceutical company Wellomics in 2014. After departing from Wellomics in 2015, Dr. Fliri developed Emergent Intelligence technology (EI) and founded Emergent System Analytics LLC (ESA). His focus shifted towards addressing unmet medical needs, including the development of products to combat drug-resistant bacterial infections, as well as viral, fungal, and parasitic infections with pandemic potential. Recognizing affordability gaps in healthcare, Dr. Fliri utilized his expertise in drug discovery and technology to decode nature's healing power and create new products that meet efficacy and safety expectations for individuals who cannot afford expensive synthetic medicines.
Dr. Fliri's research on the impact of vitamin D deficiency in weakening the immune system and its association with over 500 diseases, such as diabetes, dementia, atherosclerosis, and Alzheimer's disease, has been instrumental in the creation of Fierce Immunity. This product not only helps enhance innate immunity but also is designed to help support cardiovascular and central nervous system functions.
DR. SHAMA KAJIJI
Shama Kajiji, M.S., Ph.D., M.B.A., is a seasoned professional with a distinguished career in the pharmaceutical industry. With a focus on science-backed, functional products, she is dedicated to transforming the nutraceutical industry. Dr. Kajiji is the CEO of SystaMedic, Inc. and the CEO and Co-founder of Emergent System Analytics LLC, an operational and consulting arm.
Additionally, Dr. Kajiji is a Co-founder of Emergent Innovations, Inc., a company committed to developing medicines from sustainable natural sources. These companies are pioneers in life science data analysis and apply Systamedic’s Emergent Intelligence (EI) technology platform to seek therapeutic solutions to address global, unmet medical needs. These solutions include the huge demand for interventions to help balance the immune system – namely, Fierce Immunity. Driven by a passion for meaningful innovation, Dr. Kajiji and her colleagues strive to utilize nature's healing powers to safeguard human and animal health and wellness.
With nearly 30 years of experience, Dr. Kajiji has held prominent leadership roles at Pfizer Inc., Merck and Co., Inc., and Johnson & Johnson. She possesses extensive knowledge in the discovery and development of new medicines across various therapeutic areas. Her contributions include the successful development of two marketed anticancer drugs, Tarceva and Tremelimumab, and she holds multiple patents. Dr. Kajiji’s strategic guidance has helped position her large pharmaceutical employers as one of the top five multinational companies in China.
Dr. Kajiji's academic achievements include a B.Sc. with Honors in Microbiology from Bombay University in India, an M.S. in Immunology from the University of Rhode Island, and a Ph.D. in Biochemical Pharmacology and Experimental Pathology from Brown University, focusing on Pancreatic cancer. She completed her post-doctoral training in Cancer Research at the Scripps Clinic, where she made notable discoveries. Complementing her scientific expertise, Dr. Kajiji has furthered her knowledge with an Executive M.B.A. from the University of Rhode Island and has completed strategic leadership programs at Harvard Business School and Stanford University.
Dr. Kajiji's current areas of focus include addressing vitamin D deficiency and its comorbidities, utilizing marine sources and omega-3-containing products for waste-to-value approaches, and designing inhalable natural products for various indications such as endurance, cognition, and pain relief.
ONE-OF-A-KIND FORMULATION
Not only are the ingredients a unique, conscientiously calculated combination, but the ratios between them are too. The result is a never-before-seen synergy in our immune system supplement: Fierce Immunity.
SOURCED WITH CARE
You can feel confident that our team meticulously sources each ingredient. Every aspect of our formulas is attentively supervised. Through our ground breaking products, our commitment to top-of-the-line innovation is established.
MADE TO HARMONIZE WITH YOUR HEALTHY LIFESTYLE
When you take care of your body, your life bears more fruit. This simple truth is one we firmly believe in from firsthand experience—and we see our immune system supplement as a testament to it.
DEVELOPED BY WORLD-CLASS FORMULATORS
On the quest for an immunity supplement that had never been created before, we reached out to the best nutraceutical formulators on the planet. Thanks to proprietary formulation technology, we birthed Fierce Immunity to help arm your immune system against all the forces trying to tear it down.
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